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KMID : 0379520000160040263
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한국독성학회지
2000 Volume.16 No. 4 p.263 ~ p.267
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Antitumor Activity of 23, 24-dihydrocucurbitacin D Isolated from Bryonia alba L.
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Sohn Hyung-Ok
Lee Young-Gu
Lim Heung-Bin
Kwon Nyoun-Soo
Goorgen V. Apriklan
Lee Dong-Wook
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Abstract
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The cytotoxic and antitumor activity of 23,24-dihydrocucurbitacin D (dhc D) isolated from Bryonia alba L. was examined. Our results showed that dhc D strongly inhibited the viability of the cultured cancer cells, A-549, COLO 205, SK-MEL-2, and L121O. It also exhibited effective antitumor activity in ICR mice, which had been intra peritoneally implanted with sarcoma 180 ascites tumor cells. The dhc D also strongly inhibited the viability of immortalized macrophages RAW 264.7, but not normal peritoneal macrophages. These results indicate that dhc D has antiproliferative effect on cancer cells and it may more sensitive on immortalized cells than normal cells.
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KEYWORD
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23, 24-Dihydrocucurbitacin D (dhc D), Bryonia alba L., Cytotoxicity, Macrophages, Antitumor activity
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